This unique introduction to the foundational concepts of cyber-physical systems (CPS) describes key design principles and emerging research trends in detail. Several interdisciplinary applications are covered, with a focus on the wide-area management of infrastructures including electric power systems, air transportation networks, and health care systems. Design, control and optimization of cyber-physical infrastructures are discussed, addressing security and privacy issues of networked CPS, presenting graph-theoretic and numerical approaches to CPS evaluation and monitoring, and providing readers with the knowledge needed to operate CPS in a reliable, efficient, and secure manner. Exercises are included. This is an ideal resource for researchers and graduate students in electrical engineering and computer science, as well as for practitioners using cyber-physical systems in aerospace and automotive engineering, medical technology, and large-scale infrastructure operations.